The pattern of Helicobacter pylori antigens in patients with stomach ulcers.
Author: Amirreza Boroumand | Source: Scientific Journal of Hamadan University of Medical Sciences (2003)
Identification of Helicobacter pylori antigen
In this study, the pattern of Helicobacter pylori antigens in patients with gastric ulcers was investigated. Considering the important role of H. pylori in gastrointestinal diseases, identifying the antigens of this bacteria could help improve diagnostic and therapeutic methods.
Method of conducting research
Stomach biopsy samples were collected from patients and cultured under microaerophilic conditions in a specialized medium.
Then 25 colonies of H. pylori were isolated and the cell lysate was analyzed by SDS-PAGE. For examining the immune response, the immunoblotting method was used.
Findings related to Helicobacter pylori antigens
Two major groups of antigens were identified:
- Group one: Antigens with a molecular weight of 55 to 97 kilodaltons.
- Group two: Antigens with a molecular weight of 20 to 24 kilodaltons.
These antigens play an important role in stimulating the body’s immune response.
Clinical and diagnostic applications
The results of this research indicate that Helicobacter pylori antigens can be used as targets for the development of rapid diagnostic kits or potential vaccines. This is particularly important for patients living in areas with a high prevalence of H. pylori.
Further research
For studying the original article, you can refer to the link below: Download the article from Academia.
Related topics: